Each year, The American Society of Cataract and Refractive Surgery (ASCRS) awards the Innovator’s Medal to an individual whose innovative ideas have benefited ophthalmologists and their patients. The lecture and medal were established in 1985; its recipients include some of the world’s most prominent pioneers in ophthalmic surgery. ASCRS renamed its Innovator’s Lecture to the Charles D. Kelman Innovator’s Lecture in recognition of his life-long contributions and innovations that have benefited patients and advanced the science of ophthalmology in 2002.
Charles D. Kelman Innovators Lecturers
Theo Seiler, MD, PhD, 2008
Okihiro Nishi, MD, 2007
Kensaku Miyake, MD, 2006
Carmen A. Puliafito, MD, 2005
Roger F. Steinert, MD, 2004
Ioannis G. Pallikaris, MD, 2003
David J. Apple, MD, 2002
Gholam A. Peyman, MD, 2001
Stephen D. Klyce, PhD, 2000
David J. McIntyre, MD, 1999
Manus C. Kraff, MD, 1998
Luis A. Ruiz, MD, 1997
James P. Gills, MD, 1996
Leo D. Bores, MD, 1995
Howard Fine, MD, 1994
D. Peter Choyce, MS, FRCS, 1993
Joaquin Barraquer, MD, 1992
David Miller, MD, 1991
Robert Stegmann, MD, 1991
Herbert E. Kaufman, MD, 1990
C. William Simcoe, MD, 1989
John L. Pearce, ChM, DO, 1988
Danièle S. Aron-Rosa, MD, 1987
Steven P. Shearing, MD, 1986
Charles D. Kelman, MD, 1985
2008 Charles D. Kelman Innovator’s Lecture The Stony Way of Development of a Clinical Procedure: Collagen Crosslinking Example
Theo Seiler, MD, PhD, Zurich Switzerland
Monday, April 7, 2008
Innovator’s Session, 10:00 am
McCormick Center West, Chicago IL
The Charles D. Kelman Innovator’s Lecture Each year the American Society of Cataract and Refractive Surgery honors an individual whose innovative ideas have benefited ophthalmologists and their patients. Dr. Nishi’s extensive research and innovations in ophthalmic surgery have earned him this award.
Abstract
Clinical therapeutic or diagnostic techniques need 3 phases of development:(1) Preclinical experiments, (2) pilot study and (3) prospective studies. Using cross linking of the cornea as an example the 3 phases are described in detail.
The preclinical studies (1996-2003) included the realization of the idea, laboratory work and animal trials. In this phase, the treatment parameters as well as the efficacy of the procedure were optimized. The pilot study was commenced in 1999 and was published in 2003- In this study, the clinical feasibility was proven. It took another 2 years until patients were enrolled in multicenter prospective studies which are still underway.
Aside from the temporal and logic evolution of the clinical procedure the difficulties regarding motivation of co-workers, acceptance of new ideas and regulatory affairs will be discussed.
Theo Seiler
Dr. Seiler teaches General Ophthalmology and is specialist in corneal and refractive therapy, physiologic optics, lasers in ophthalmology, and anterior segment surgery. He was born in Ravensburg, Southern Germany in 1949. He studied medicine, mathematics, and physics at the Universities of Heidelberg and Berlin. In 1976, he because a professor of physics at the Peter-Silbermann College in Berlin. He began his residency at the Department of Ophthalmology at the Free University of Berlin in 1981, where he was rose to senior assistant and lecturer in 1985 and became a professor of ophthalmology in 1990. In 1993, Dr. Seiler became Professor and Chairman of the Department of Ophthalmology, at Technische Universität of Dresden, which is a unique interdisciplinary center focusing on research and teaching. In 2000, Dr. Seiler assumed his current position as Professor and Chairman of the Department of Ophthalmology at the University of Zurich in Switzerland.
Among his many awards areBinkhorst Award (American Academy of Ophthalmology), 1994; the Barraquer Award (American Academy of Ophthalmology) 1995; the Graefe Award (Deutsche Ophthalmologische Gesellschaft), 1996; and the Honor Award (American Academy of Ophthalmology), 1997.
